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Archiv-Übersicht     Angebot Nr. 14363

Angebotsdatum: 20. Januar 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Genetik
Titel des Themas: The impact of plant antibiotic metabolites and bacterial multidrug resistance genes on the root microbiota composition

Institut: LMU München Biozentrum
Prof. Parniske
Großhaderner Str. 4
82152 Planegg-Martinsried
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://https://www.genetik.bio.lmu.de/research/parniske/opportunities/index.html
E-Mail Kontakt: mail

Beschreibung: Plant species differ widely in the chemical spectrum of phytochemicals with antimicrobial properties (“antibiotics”) they produce. This may be one of the reasons, why soil bacteria are a major reservoir of antibiotic resistance genes. This project aims to explore to what extend such resistance genes contribute to bacterial survival and competitiveness in and on toxin-producing roots. To this end, we will identify a) toxic compounds from root exudates and b) bacterial resistance genes that protect against these in collaboration with experts in a) plant metabolite analysis and chemistry (Corinna Dawid, TUM) and b) microbiome analysis (Michael Schloter, HMGU). To determine the impact of specific compounds with antibiotic activity on the root microbiome composition, the project will, among other tools, employ plant mutants defective for their biosynthesis. On the bacterial side, we will study the contribution of bacterial multidrug resistance (MDR) genes to increased resistance against specific plant-derived toxins and thus to successful root colonization and competition with other microbiota. We aim to determine whether specific antibiotic compounds within the host root exudate in combination with cognate rhizobial antibiotic resistance genes contributes to the host specificity of the legume-rhizobium symbiosis. The knowledge gained in this project will help informed selection of plant beneficial bacterial inoculants for sustainable agricultural practises.
Anfangsdatum: 1. Februar 2022
Geschätzte Dauer: 3+ Jahre
Sonstiges: The Parniske laboratory is situated in the Biocenter of the University of Munich (LMU), Germany. The Biocenter is equipped with state-of-the-art instrumentation to carry out molecular, biochemical and cell biological research, and can be conveniently reached by public transport from the city center of Munich.
For further information about the Parniske lab please visit: www.genetik.biologie.uni-muenchen.de
To apply, please send your application via email to Martin Parniske (parniske@lmu.de) with a referral to this advert ("Positions offered August 2021") in your cover letter and subject line of your email.
Ideally, your application includes all materials required for an application at the LSM at LMU (this list applies also to postdoctoral applicants) but at the very least your curriculum vitae, names of two referees, a motivation letter and a qualification statement.
The motivation letter must include which project you are applying for and an explanation why you are interested in this particular project. The content must thus go beyond general non-project related statements like "the LMU is a great university".
Please also explain in a qualification statement on a separate page what makes you particularly qualified to carry out the project you applied for.
If you found this page by searching for a PhD student position, you should apply for one of the doctoral candidates positions we offer, leading to the German degree "Dr. rer. nat." which is at least as good as - but legally not identical to - a "Ph.D.".