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Archiv-Übersicht     Angebot Nr. 14467

Angebotsdatum: 8. März 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biologie
Titel des Themas: PhD student position in translational cancer research

Institut: Institut für Pathologie
Adresse:
Prof. Monika Hämmerle
Institut für Pathologie, Magdeburger Straße 14
06112 Halle (Saale)
Tel.:    Fax.:
Bundesland:
Homepage: http://https://www.medizin.uni-halle.de/forschung/nachwuchsgruppen/ag-experimentelle-pathologie-ag-haemmerle
E-Mail Kontakt: mail

Beschreibung: The junior research group "Experimental Pathology" (Head: Jun.-Prof. Dr. Monika Hämmerle) at the Martin-Luther-University Halle-Wittenberg, Germany, is seeking a highly motivated PhD student who is passionate about translational cancer research.

The advertised PhD student position (13 TV-L, 65%) is available within the newly established Research Training Group RTG2751 “Inflammatory cues as modulators of early pancreatic carcinogenesis (InCuPanC)” fully funded by the German Research Foundation (DFG). The RTG2751 provides a structured post-graduate training program including various workshops and seminars supporting students in establishing a successful scientific career. The research consortium RTG2751 is a highly interdisciplinary network of clinical scientists and biomedical researchers, providing expert knowledge in both pre-clinical and translational pancreatic cancer research including relevant genetic in vivo models serving as central platform for different inflammatory triggers of pancreatic carcinogenesis, as well as state-of-the-art transcriptomics, proteomics and CRISPR-based screening methods, thereby enabling excellent interdisciplinary training for PhD students.

The position is available immediately and initially limited for three years with a possibility of extension.

The lab is embedded in an excellent research environment within the Charles-Tanford-Protein Centre with state-of-the-art research equipment and infrastructure (e.g. FACS Melody, confocal laser scanning microscopy, IncuCyte S3, Mass-Spectrometry). We are mainly interested in understanding the role of signaling pathways important for tumor growth and metastasis, thereby focusing on tumor cell autonomous and non-autonomous mechanisms.
The main goal of the herein advertised PhD project (Project B5) is to characterize the role of platelets in the regulation of tumor initiation and progression in early pancreatic carcinogenesis in vitro and in vivo. Own preliminary work has shown a significant impact of platelets on tumor growth and metastasis (JCI 2016; Nature Comm 2017; Blood 2017; MCT 2017; Cancer Cell 2018), which we would like to characterize further, thereby focusing on the regulation of the tumor immune microenvironment by platelets.

For more information, please visit: https://www.medizin.uni-halle.de/forschung/nachwuchsgruppen/ag-experimentelle-pathologie-ag-haemmerle

To be eligible for this position, applicants must hold a Diploma or Master’s degree in the field of molecular biology, biochemistry, molecular medicine, bioinformatics, or a related discipline. The successful candidate is a highly motivated, innovative, self-driven individual with excellent grades who is passionate about making a difference through cancer research. A reliable and accurate scientific working ethic, and the ability to work efficiently, independent as well as in a team, is a necessity. An excellent written and oral command of English paired with strong communication skills is essential. The ideal candidate has a solid background in the field of cancer biology and expertise in molecular and cellular biology, with a specific focus on the techniques described above.
We offer a close supervision, individual mentoring and excellent training opportunities, both in laboratory techniques as well as soft skills. For examples, students will have the opportunity to attend seminars / workshops, present their results at conferences and write manuscripts.

If you are interested in this opportunity, please submit your full application (in electronic form preferentially as a single pdf) mentioning the registration number 7-251/21-D in the subject line until 25. January 2022 to Jun.-Prof. Dr. Monika Hämmerle (E-mail: monika.haemmerle@uk-halle.de). The application should consist of (I) a letter of motivation, (II) a recent curriculum vitae incl. an overview of techniques and methods used in the past, (III) academic degrees and certificates, (IV) other skills and interests relevant for this position, and (V) contact information of two references.
Methoden:
Anfangsdatum: 1. April 2022
Geschätzte Dauer: 3 years
Bezahlung: E13 TV-L 65%
Papers: https://www.mdpi.com/1422-0067/21/20/7614

https://www.sciencedirect.com/science/article/pii/S1535610818300709?via%3Dihub

https://www.nature.com/articles/s41467-017-00411-z

https://ashpublications.org/blood/article/130/10/1235/36354/Role-of-ADP-receptors-on-platelets-in-the-growth

https://www.jci.org/articles/view/85086
Sonstiges:

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