|| The Kaether Group “Membrane Trafficking in Aging” at FLI invites applications for a Doctoral Position (m/f/d)
The Kaether group is interested in all aspects of membrane trafficking, especially in structure and function of the endoplasmic reticulum (ER), ER-Golgi transport and its role in aging and in neurodegenerative diseases.
Tasks and Challenges:
The project is funded by the Deutsche Forschungsgemeinschaft within ProMoAge, a research training group that investigates posttranslational modifications (PTMs) of proteins as key mechanisms in aging.
In the project Role of PTMs in senescent-induced transformation of the secretory pathway we are interested in senescence-induced changes in phosphorylation, ubiquitinylation and acetylation of proteins in the early secretory pathway and their functional implications on the senescent-associated secretory phenotype, a key property of senescent cells. The applicants task is to identify the PTMs using mass-spectroscopy based techniques. PTMs will be functionally characterized using cell biological and biochemical tools (construction of fusion proteins, confocal-, live- and super resolution-microscopy, Western Blot, Co-immunoprecipitation, siRNA, shRNA, CRISPR). The impact of PTMs on the early secretory pathway will be determined, resulting in a comprehensive study linking phosphorylation, ubiquitinylation and acetylation of proteins in the early secretory pathway to senescence-induced cellular changes.
- University Degree (master or equivalent) in Biology, Life Science or Biophysics or related fields)
- highly self-motivated with a genuine interest and ideally previous experience in cell biology.
- excellent team-working capabilities.
interest in multi-disciplinary training in aging research
- Fluent English, the working language at FLI and in Promoage
- a position in a well-equipped research group in a high quality institute for age research, which harbours several state-of-the-art facilities. Our institute is embedded in the Beutenberg Campus, an interdisciplinary base for innovative research.
- Embedding in the graduate programs of Promoage and LGSA.
- Three year funding with the possibility of extension. The contract conditions and the salary will be according to the collective labour agreement for public service employees of the federal states of Germany (TV-L E13)
Candidates are encouraged to get familiar with the guidelines for application for LGSA. The advert is part of the general LGSA advert 22/09. Please use the online platform of the LGSA advert to apply: