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Archiv-Übersicht     Angebot Nr. 14564

Angebotsdatum: 20. April 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Biophysik
Titel des Themas: Experimental Molecular Biophysics of protein folding and misfolding in neurodegenerative diseases (65% TV-L E13, 36 months)

Institut: Freie Universität Berlin
Dr. rer. nat. Jacek Jacek Kozuch
Arminallee 14
14195 Berlin
Tel.: 030 838 64888   Fax.:
Bundesland: Berlin
Homepage: http://https://kozuchlab.com/
E-Mail Kontakt: mail

Beschreibung: The Kozuch group investigates the function of biomedically relevant (membrane) proteins with a special focus on electrostatic interactions that shape the formation of functional motifs. The methodological approach is based on a combination of (nanoscopic) vibrational spectroscopy supplemented by the use of model membrane systems, biochemical methods and computer-aided simulations. After completing his doctoral thesis in biophysical chemistry at the Technical University of Berlin, Dr. Jacek Kozuch did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at Freie Universität Berlin and the new building for research into supramolecular functional architectures at biointerfaces.
We offer:
• the opportunity for a PhD within the stimulating, interdisciplinary and
international environment of Freie Universität Berlin,
• the entry into fascinating and biomedically relevant topics of molecular
• the use and further development of modern vibrational spectroscopic methods.

This DFG-funded project aims to research how specific interactions with membranes for folding or misfolding of, e.g., β-amyloid or islet amyloid polypeptide can lead to neurodegenerative diseases. For this purpose, surface-enhanced (SEIRAS) and AFM-based nano-infrared spectroscopy (nanoIR) in combination with model membrane systems will be used to track folding trajectories and control them through various boundary conditions.
The area of responsibility includes:
• the independent conduction of this scientific project,
• the biochemical preparation of protein/peptide samples and the construction of membrane model systems,
• the implementation of nanoscopic and surface-enhanced infrared spectroscopy measurements,
• participation in international conferences.
Methoden: • construction of bilayer lipid membranes,
• surface-enhance IR absorption (SEIRA) spectroscopy,
• atomic force microscopy (AFM),
• nanoscale IR spectroscopy (combining AFM and IR)
Anfangsdatum: 1. Juli 2022
Geschätzte Dauer: 36 Month
Bezahlung: 65 % TVL E13
Papers: J. Kozuch, C. Steinem, P. Hildebrandt,* D. Millo*
Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes. Angew. Chem. Int. Ed., 2012, 51, 8114-8117. https://doi.org/10.1002/anie.201203214

E. Forbrig, J. K. Staffa, J. Salewski, M. A. Mroginski, P. Hildebrandt, J. Kozuch,*
Monitoring the orientational changes of alamethicin during incorporation in bilayer lipid membranes, Langmuir, 2018, 34, 2373-2385.
Sonstiges: Recruitment requirements:
Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, biochemistry or in one of the related natural sciences.

Experience with vibrational spectroscopic methods and/or atomic force microscopy; handling biological samples (e.g., proteins); willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; Fun and fascination with science, especially in the field of molecular biophysics.

Further information is given by Dr. Jacek Kozuch (jacek.kozuch@fu-berlin.de / 03083864888).

Additional Information
Applications (including cover letter, CV, certificates, one letter of recommendation as a signle PDF) should be sent electronically by e-mail to Dr. Jacek Kozuch: jacek.kozuch@fu-berlin.de or by mail to

Free University of Berlin
Department of Physics
Institute for Experimental Physics
Experimental Molecular Biophysics
Dr. Jacek Kozuch
Arnimallee 14
14195 Berlin (Dahlem)

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