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Archiv-Übersicht     Angebot Nr. 14564

Angebotsdatum: 20. April 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Biophysik
Titel des Themas: Experimental Molecular Biophysics of protein folding and misfolding in neurodegenerative diseases (65% TV-L E13, 36 months)

Institut: Freie Universität Berlin
Adresse:
Dr. rer. nat. Jacek Jacek Kozuch
Arminallee 14
14195 Berlin
Tel.: 030 838 64888   Fax.:
Bundesland: Berlin
Homepage: http://https://kozuchlab.com/
E-Mail Kontakt: mail

Beschreibung: The Kozuch group investigates the function of biomedically relevant (membrane) proteins with a special focus on electrostatic interactions that shape the formation of functional motifs. The methodological approach is based on a combination of (nanoscopic) vibrational spectroscopy supplemented by the use of model membrane systems, biochemical methods and computer-aided simulations. After completing his doctoral thesis in biophysical chemistry at the Technical University of Berlin, Dr. Jacek Kozuch did research as a postdoc at Stanford University (USA) and is now a junior research group leader within Experimental Molecular Biophysics at Freie Universität Berlin and the new building for research into supramolecular functional architectures at biointerfaces.
We offer:
• the opportunity for a PhD within the stimulating, interdisciplinary and
international environment of Freie Universität Berlin,
• the entry into fascinating and biomedically relevant topics of molecular
Biophysics,
• the use and further development of modern vibrational spectroscopic methods.

Responsibilities:
This DFG-funded project aims to research how specific interactions with membranes for folding or misfolding of, e.g., β-amyloid or islet amyloid polypeptide can lead to neurodegenerative diseases. For this purpose, surface-enhanced (SEIRAS) and AFM-based nano-infrared spectroscopy (nanoIR) in combination with model membrane systems will be used to track folding trajectories and control them through various boundary conditions.
The area of responsibility includes:
• the independent conduction of this scientific project,
• the biochemical preparation of protein/peptide samples and the construction of membrane model systems,
• the implementation of nanoscopic and surface-enhanced infrared spectroscopy measurements,
• participation in international conferences.
Methoden: • construction of bilayer lipid membranes,
• surface-enhance IR absorption (SEIRA) spectroscopy,
• atomic force microscopy (AFM),
• nanoscale IR spectroscopy (combining AFM and IR)
Anfangsdatum: 1. Juli 2022
Geschätzte Dauer: 36 Month
Bezahlung: 65 % TVL E13
Papers: J. Kozuch, C. Steinem, P. Hildebrandt,* D. Millo*
Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes. Angew. Chem. Int. Ed., 2012, 51, 8114-8117. https://doi.org/10.1002/anie.201203214

E. Forbrig, J. K. Staffa, J. Salewski, M. A. Mroginski, P. Hildebrandt, J. Kozuch,*
Monitoring the orientational changes of alamethicin during incorporation in bilayer lipid membranes, Langmuir, 2018, 34, 2373-2385.
https://doi.org/10.1021/acs.langmuir.7b04265
Sonstiges: Recruitment requirements:
Completed scientific university studies (diploma, master) in physics, chemistry, biophysics, biochemistry or in one of the related natural sciences.

Desirable:
Experience with vibrational spectroscopic methods and/or atomic force microscopy; handling biological samples (e.g., proteins); willingness to work in an interdisciplinary environment; friendly and communicative demeanor; ability to work in a team; structured and independent work; knowledge of English; Fun and fascination with science, especially in the field of molecular biophysics.

Further information is given by Dr. Jacek Kozuch (jacek.kozuch@fu-berlin.de / 03083864888).

Additional Information
Applications (including cover letter, CV, certificates, one letter of recommendation as a signle PDF) should be sent electronically by e-mail to Dr. Jacek Kozuch: jacek.kozuch@fu-berlin.de or by mail to

Free University of Berlin
Department of Physics
Institute for Experimental Physics
Experimental Molecular Biophysics
Dr. Jacek Kozuch
Arnimallee 14
14195 Berlin (Dahlem)

By submitting an online application, you as the applicant agree that your data will be processed and stored electronically.
We would like to point out that Freie Universität Berlin cannot guarantee the security of transmitted personal data if your application is sent electronically without protection.

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