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Archiv-Übersicht     Angebot Nr. 14574

Angebotsdatum: 29. April 2022
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: Regulation of Mitochondrial Function and Biogenesis

Institut: Department of Medical Biochemistry and Cell Biology, University of Gothenburg
Adresse:
Prof. Martin Ott
Medicinaregatan 9A
40530 Göteborg
Tel.: 0046722612871   Fax.:
Bundesland:
Homepage: http://www.martinottlab.com
E-Mail Kontakt: mail

Beschreibung: We are seeking a highly motivated and talented master or PhD student to join our new group at the Department of Medical Biochemistry and Cell Biology at Sahlgrenska Academy, Gothenburg University, Sweden.

Mitochondria are key organelles that convert chemical energy into ATP by utilizing a system of molecular machines, the respiratory chain complexes. Cells can direct metabolism depending on the availability of certain energy sources. This then requires a reprogramming of metabolism, often accompanied by changes in gene expression and the repression of competing metabolic pathways. In the frame of a five-year project funded by the Knut and Alice Wallenberg Foundation, we aim to unravel the fundamental molecular mechanisms of mitochondrial protein synthesis, its regulation and connection to respiratory chain assembly. In this project, we will study the adjustment of mitochondrial functions in cells exposed to insulin and other stimuli that can inhibit mitochondrial functions including organellar protein synthesis. Our group employs a wide array of methodology including human cell culture, molecular biology, biochemistry, and structural biology.
Successful applicants would have a background in biochemistry, molecular biology or a related field. Previous experience with cell culture or microscopy would be desirable, but is not a strict requirement. Starting date is flexible. Please send a cover letter stating your research interests and a curriculum vitae with your research experience and courses taken, merged into a single pdf file to martin.ott@gu.se
If you have further questions, please contact:
Martin Ott
Phone: 0046-722612871
E-mail: martin.ott@gu.se
Homepage: www.martinottlab.com
Researchgate: https://www.researchgate.net/profile/Martin_Ott2
Methoden: Humane Zellkultur, Biochemie, Molekularbiologie, Strukturbiologie, Hefegenetik
Anfangsdatum: 29. April 2022
Geschätzte Dauer: Diplomarbeit: 6-12 Monate, Doktorarbeit: 4,5 Jahre
Bezahlung: Diplomarbeit: Stipendium, Doktroarbeit: Volles Geh
Papers: 5. Singh AP*, Salvatori R*, Aftab W, Aufschnaiter A, Carlström A, Forne I, Imhof A, Ott M. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Mol Cell. 2020;79(6):1051-1065.

4. Toth A, Meyrat A, Stoldt S, Santiago R, Wenzel D, Jakobs S, von Ballmoos C§, Ott M. Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes. PNAS 2020 ;117(5):2412-2421.

3. Salvatori S*, Kehrein K*, Singh AP, Aftab W, Vargas Möller-Hergt B, Forne I, Imhof A, Ott M. Molecular wiring of a mitochondrial translational feedback loop. Mol Cell 2020: 77(4):887-900

2. Rathore S*, Berndtsson J*, Marin-Buera L*, Conrad J, Carroni M, Brzezinski P, Ott M. Cryo-EM structure of the yeast respiratory supercomplex. Nat Struct Mol Biol. 2019;26(1):50-57.

1. Suhm T, Kaimal JM, Dawitz H, Peselj C, Masser AE, Hanzén S, Ambrožič M, Smialowska A, Björck ML, Brzezinski P, Nyström T, Büttner S, Andréasson C, Ott M. Mitochondrial translation efficiency controls cytoplasmic protein homeostasis. Cell Metabol. 2018;27(6):1309-1322.
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