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| Angebotsdatum: |
9. Mai 2022
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| Art der Stelle: |
Doktorarbeit |
| Fachgebiet: |
Biologie > Molekularbiologie
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| Titel des Themas: |
PhD student (m/f/d) in chromatin biochemistry
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| Institut: |
Institut für Biologie
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| Adresse: |
| Prof. Ann Ehrenhofer-Murray |
| Philippstr. 13, Haus 22 |
| 10099 Berlin |
| Tel.: 030 2093 49630 Fax.:
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| Bundesland: Berlin |
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| Homepage: |
http://https://www.biologie.hu-berlin.de/de/gruppenseiten/cellbio
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| E-Mail Kontakt: |
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| Beschreibung: |
Faculty of Life Sciences – Institute of Biology
PhD student (m/f/d) in chromatin biochemistry with 2/3 part-time employment, for 3 years - E13 TV-L HU
Starting date: August 1, 2022 or thereafter
Responsibilities:
- Research and teaching in the field of genetics, molecular biology and epigenetics
- Research on chromatin regulation and epigenetics in Saccharomyces cerevisiae, in particular biochemical and structural biological studies of heterochromatin components and their binding to nucleosomes using biochemical and structural biological methods in combination with molecular genetics to characterize repressed chromatin
- Tasks for your own scientific qualification (doctorate)
Requirements:
- University degree in biology, biochemistry or similar topic
- Proven experience in biochemistry and structural biology
- Knowledge of chromatin and epigenetics desired
- Good German and English skills, both written and spoken
- Be highly motivated, creative and self-driven
Please send applications (including cover letter, curriculum vitae and relevant certificates; reference: AN/105/22) to the Humboldt University of Berlin, Faculty of Life Sciences, Institute of Biology, Prof. Ehrenhofer-Murray, (Sitz: Philippstr. 13, Haus 22), Unter den Linden 6, 10099 Berlin or preferably by e-mail in a PDF file to ann.ehrenhofer-murray@hu-berlin.de. Deadline for applications: June 15, 2022
To ensure equality, applications from qualified women are particularly welcome. Severely disabled people will be given preference if they are equally qualified. Applications from people with a migration background are encouraged. Since we do not return your documents, we ask that you only enclose copies with your application.
Information on data protection law regarding the processing of your personal data as part of the job advertisement and selection process can be found on the homepage of the Humboldt University of Berlin: https://hu.berlin/DSGVO.
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| Methoden: |
Recombinant protein expression and purification
In vitro reconstitution of chromatin
Cryo-electron microscopy
Molecular biology
Yeast molecular genetics
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| Anfangsdatum: |
1. August 2022 |
| Geschätzte Dauer: |
36 months
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| Bezahlung: |
2/3 part-time employment, E13 TV-L HU
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| Papers: |
1. Samel, A., Rudner, A. and A Ehrenhofer-Murray (2017) Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae. G3 (Bethesda) 7(4): 1117-1126.
2. Boltengagen M, Samel-Pommerencke A, Fechtig D, Ehrenhofer-Murray AE. (2021) Dynamics of SAS-I mediated H4 K16 acetylation during DNA replication in yeast. PLoS One. 2021 May 20;16(5):e0251660.
3. Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE (2011) Structural basis for the role of the Sir3 AAA+ domain in silencing
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