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Archiv-Übersicht     Angebot Nr. 14581

Angebotsdatum: 10. Mai 2022
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Mechanisms of macrophage polarization in macular degeneration and wounds

Institut: Harvard Medical School/Massachusetts General Hospital
Adresse:
Prof. Alexander Marneros
13th Street, Charlestown
02129 Boston, USA
Tel.:    Fax.:
Bundesland:
Homepage: http://https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab
E-Mail Kontakt: mail

Beschreibung: Position on macrophage polarization available at Massachusetts General Hospital/Harvard Medical School

Laboratory for Macrophage Biology and Inflammation

(PI: Alexander G. Marneros, MD/PhD)


Project: “Molecular pathways and therapeutic interventions affecting macrophage polarization and the role of macrophages in neovascular age-related macular degeneration”.

We are investigating molecular mechanisms that control macrophage polarization and the role that activated macrophages play for inflammation, pathological angiogenesis and fibrosis. We have established in vitro assays to identify regulators of macrophage polarization. Chemical screens identified pharmacologic inhibitors of IL-4-induced macrophage polarization that can also block macrophage-induced angiogenesis and fibrosis in disease models, including in neovascular age-related macular degeneration (JBC, 2016; Cell Reports, 2021). This project aims to identify new therapies that target the molecular pathways that are critical for macrophage polarization and that influence the ability of activated macrophages to induce pathological angiogenesis in conditions such as age-related macular degeneration, cancer or wound healing.

Our laboratory utilizes diverse experimental techniques and has long-standing expertise in mouse genetics, molecular biology, and imaging techniques. We are embedded within a highly interactive excellent research environment at Massachusetts General Hospital and Harvard Medical School. Our research projects involve epithelial biology, wound healing, angiogenesis and inflammation. This allows exposure to diverse but overlapping areas of research. Much of our work has clinical and translational relevance.

Requirements:
1. Expertise in molecular biology techniques and in vivo work with mouse models
2. Working well within a team, excellent work ethic and being well organized
3. excellent written and verbal communication skills, demonstrate critical thinking and independent problem-solving abilities

To apply, please send (1) cover letter highlighting past research experience, your research interests and career goals, (2) CV and (3) the contact info of three references via email to Alexander Marneros, MD/PhD, Associate Professor, Harvard Medical School, Massachusetts General Hospital at amarneros@mgh.harvard.edu

https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab
Methoden:
Anfangsdatum: 10. Mai 2022
Geschätzte Dauer: mindestens 1 Jahr
Bezahlung:
Papers:
Sonstiges:

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