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Archiv-Übersicht     Angebot Nr. 14582

Angebotsdatum: 10. Mai 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: “Mechanisms of terminal differentiation of nephron epithelium in the kidney and of skin epidermis”.

Institut: Harvard Medical School/Massachusetts General Hospital
Adresse:
Prof. Alexander Marneros
13th Street
02129 Boston, USA
Tel.:    Fax.:
Bundesland:
Homepage: http://https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab
E-Mail Kontakt: mail

Beschreibung: Position on Epithelial Differentiation available at Massachusetts General Hospital/Harvard Medical School


(PI: Alexander G. Marneros, MD/PhD)


Project: “Mechanisms of terminal differentiation of nephron epithelium in the kidney and of skin epidermis”.

We have recently identified a novel critical regulator of terminal epithelial differentiation in the kidney that is required for proper nephron development and for kidney functions in the adult (Dev Cell, 2020; Cell Reports, 2021; Nature Communications, 2022). Our data suggest a previously not appreciated role of defects in epithelial differentiation in the kidney for the manifestation of renal fibrosis with progressive age. By utilizing new conditional mutant mice we are investigating the specific spatiotemporal roles of this epithelial regulator in the kidney. Moreover, overlapping mechanisms also affect keratinocyte differentiation in the skin. This project aims to elucidate novel molecular pathways that control epithelial differentiation in the kidney and the skin.

Our laboratory utilizes diverse experimental techniques and has long-standing expertise in mouse genetics, molecular biology, and imaging techniques. We are embedded within a highly interactive excellent research environment at Massachusetts General Hospital and Harvard Medical School. Our research projects involve epithelial biology, wound healing, angiogenesis and inflammation. This allows exposure to diverse but overlapping areas of research. Much of our work has clinical and translational relevance.

Requirements:
1. Expertise in molecular biology techniques and in vivo work with mouse models
2. Working well within a team, excellent work ethic and being well organized
3. excellent written and verbal communication skills, demonstrate critical thinking and independent problem-solving abilities

To apply, please send (1) cover letter highlighting past research experience, your research interests and career goals, (2) CV and (3) the contact info of three references via email to Alexander Marneros, MD/PhD, Associate Professor, Harvard Medical School, Massachusetts General Hospital at amarneros@mgh.harvard.edu

https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab
Methoden:
Anfangsdatum: 10. Mai 2022
Geschätzte Dauer: >1 Jahr
Bezahlung:
Papers:
Sonstiges:

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