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Archiv-Übersicht     Angebot Nr. 14585

Angebotsdatum: 11. Mai 2022
Art der Stelle: Diplomarbeit
Fachgebiet: Biologie > Anthropologie
Titel des Themas: Master Thesis Positions in Epigenetic regulation of Heart Development and Disease

Institut: European Center for Angioscience - Heidelberg University
Adresse:
Frau Gergana Dobreva
Ludolf-Krehl-Str. 7-11
68167 Mannheim
Tel.: +494962138371472   Fax.:
Bundesland:
Homepage:
E-Mail Kontakt: mail

Beschreibung: We are looking for highly masters students to work on the transcriptional and epigenetic events elicited by cell-to-cell communications during cardiovascular development and disease.
Dynamic interactions between endothelial cells, cardiomyocytes and fibroblasts are crucial for heart morphogenesis, postnatal cardiac growth, contractile performance and rhythmicity. At a molecular level, these dynamic cell interactions induce signalling cascades, which converge to induce transcriptional and epigenetic programming that directs cell behaviour and regulates heart function. Our aim is to decipher the transcriptional and epigenetic events regulating the heterocellular crosstalk in the cardiovascular system.

The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.
To apply, please send an application letter, CV and contact information of at least one referee to Prof. Dr. Gergana Dobreva (Gergana.Dobreva@medma.uni-heidelberg.de).
Methoden: We use a wide range of biochemical, molecular/cell biological, embryological and transgenic techniques to study cardiovascular development and disease both in vitro (cell culture) and in vivo in mouse and zebrafish.
Anfangsdatum: 11. Mai 2022
Geschätzte Dauer: 3-6 months
Bezahlung:
Papers: Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G. “Pioneering function of Isl1 in epigenetic control of cardiomyocyte cell fate.” Cell Research, 2019 Jun;29(6):486-501.
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.” J Clin Invest. 2017 Jun 1;127(6):2235-2248.
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99
Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.
Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. “The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity” Dev Cell 2012, 23(1):58-70
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