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Archiv-Übersicht     Angebot Nr. 14683

Angebotsdatum: 14. September 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: cAMP signaling in astrocytes in neuroinflammation

Institut: Neurophysiology
Prof. Christian Lohr
Martin-Luther-King-Pl. 3
20146 Hamburg
Tel.:    Fax.:
Bundesland: Hamburg
Homepage: http://https://www.biologie.uni-hamburg.de/en/forschung/molekular-und-zellbiologie/neurophys.html
E-Mail Kontakt: mail

Beschreibung: The central goal of the SFB 1328 is to further our understanding of the regulatory roles of intracellular adenine nucleotides (cAMP, NAADP) as well as extracellular adenine nucleotides (ATP, ADP) and their kinetics in the context of inflammatory diseases. The Division of Neurophysiology investigates the role of astrocytes in brain function and pathophysiology (neuroinflammation). We employ two-photon/confocal calcium and cAMP imaging combined with patch-clamp electrophysiology, optogenetics and immunohistology. The successful candidate will be part of the team that uses these techniques to study second messenger signaling in astrocytes in acute brain slices of the hippocampus and the olfactory bulb. Performing and analysing imaging experiments as well as antibody staining of fixed tissue will be part of the duties.
Methoden: - confocal and two-photon microscopy
- calcium and cAMP imaging
- immunohistochemistry
- patch-clamp electrophysiology
- optogenetics
Anfangsdatum: 14. September 2022
Geschätzte Dauer: 42 Monate
Bezahlung: E13 TV-L (65%)
Papers: - Lohr C, Beiersdorfer A, Fischer T, Hirnet D, Rotermund N, Sauer J, Schulz K, Gee CE (2021) Using genetically encoded calcium indicators to study astrocyte physiology: A field guide. Front. Cell. Neurosci. doi: 10.3389/fncel.2021.690147.
- Beiersdorfer A, Scheller A, Kirchhoff F, Lohr C (2019). Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca2+ transients and neurovascular coupling. GLIA 67:1385-1400. doi: 10.1002/glia.23613.
- Fliegert R, Heeren J, Koch-Nolte F, Nikolaev V, Lohr C, Meier C, Guse AH (2019). Adenine nucleotides as paracrine mediators of and intracellular second messengers in immunity and inflammation. Biochem. Soc. Trans.47:329-337. doi: 10.1042/BST20180419.
Sonstiges: As a University of Excellence, Universität Hamburg is one of the strongest research universities in Germany. As a flagship university in the greater Hamburg region, it nurtures innovative, cooperative contacts to partners within and outside academia.
It also provides and promotes sustainable education, knowledge, and knowledge exchange locally, nationally, and internationally.
Severely disabled and disabled applicants with the same status will receive preference over equally qualied non-disabled applicants.
Contact: Prof. Dr. Christian Lohr, christian.lohr@uni-hamburg.de

Reference number: 379

Application deadline: 2022-10-05

Send us your complete application documents (cover letter, curriculum vitae, copies of degree certicate[s] and if necessary ID attesting to your disability or proof of equivalent status) via the online application form only.