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Archiv-Übersicht     Angebot Nr. 14703

Angebotsdatum: 17. Oktober 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Natural Product Research

Institut: Chemische Biologie
Prof. Lena Barra
Universitätsstraße 10
78464 Konstanz
Tel.: +497531885766   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://https://www.chemie.uni-konstanz.de/ag-barra/
E-Mail Kontakt: mail

Beschreibung: A doctoral position is available ASAP in the workgroup of Prof. Dr. Lena Barra in the Department of Chemistry. The research focus of the group lies on the investigation of the genetic and enzymatic basis of natural product biosynthesis and aims at the discovery of novel lead structures for drug development and unique enzyme-mediated chemistries to contribute to sustainable access to pharmaceuticals and fine chemicals. Therefore, we combine state-of-the-art techniques from organic synthesis, metabolomics, genomics, molecular biology, and enzymology and are looking for motivated students with enthusiasm and fascination for interdisciplinary research at the interface of chemistry and biology.

Your Competencies:
- Completed master's degree in chemical biology, organic chemistry, biochemistry, biotechnology, pharmacy, or related disciplines
- Expertise in organic chemistry, molecular biology, enzymology, mass spectrometry/metabolomics, or bioinformatics
- High motivation to learn novel techniques and work in a collaborative team
- Strong written and oral communication skills in English

We offer:
- Cutting-edge research projects and supportive mentoring
- Inclusive environment and guidance of individual career development
- State-of-the-art equipment and scientific infrastructure
- Opportunities for international, national, and in-house collaborations
Anfangsdatum: 17. Oktober 2022
Geschätzte Dauer: 3 years
Papers: Enzyme discovery and mechanism:
L. Barra, T. Awakawa, K. Shirai, Z. Hu, G. Bashiri, I. Abe, NAD as a building block in natural product biosynthesis, Nature 2021, 600, 754-758. DOI:10.1038/s41586-021-04214-7.

Biocatalysis/chemoenzymatic synthesis:
T. Mitsuhashi,* L. Barra,* Z. Powers,* V. Kojasoy,* A. Scharf, A. Cheng, F. Yang, Y. Taniguchi, T. Kikuchi, M. Fujita, D. J. Tantillo, J. A. Porco Jr., I. Abe, Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids, Angew. Chem. Int. Ed. 2020, 59, 23772-23781. DOI: 10.1002/anie.202011171.

Enzyme mechanism/isotopic labeling:
L. Barra, K. Ibrom, J. S. Dickschat, Structural Revision and Biosynthesis of Hypodoratoxide by 13C,13C-COSY-NMR, Angew. Chem. Int. Ed. 2015, 54, 6637-6640. DOI: 10.1002/anie.201501765.
Sonstiges: Start date flexible.