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Archiv-Übersicht     Angebot Nr. 14707

Angebotsdatum: 20. Oktober 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Mikrobiologie
Titel des Themas: MetaboArchaea - D-Mannose and D-fructose utilization in members of the Sulfolobales – Significance of the upper Embden-Meyerhof-Parnas pathway

Institut: Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Frau Bettina Fischer
Inhoffenstraße 7B
38124 Braunschweig
Tel.: 0531/2616-0   Fax.:
Homepage: http://www.dsmz.de
E-Mail Kontakt: mail

Beschreibung: The Department of Services of the Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig offers for the next possible date a

PhD student position (m/f/d) on

MetaboArchaea - D-Mannose and D-fructose utilization in members of the Sulfolobales – Significance of the upper Embden-Meyerhof-Parnas pathway

Archaea have been established as the third domain of life besides Bacteria and Eukaryotes 42 years ago. Most cultivable archaeal species are adapted to extreme environmental conditions. These so called ‘extremophiles’ thrive in hostile habitats characterized by extremes of temperature, pH, salt or combination thereof. Regarding their metabolic complexity Archaea resemble Bacteria and lower Eukaryotes. However, they are characterized by many new, unusual pathways and enzymes with new regulatory properties, which often share no similarity with their bacterial and eukaryotic counter-parts. Even the classical generic pathways involved in central carbohydrate metabolism are modified and the degradation of many carbon sources is still unknown. This offers exciting potential for exploitation in white biotechnology, metabolic engineering as well as synthetic biology but also hampers a profound understanding of archaeal metabolism and physiology.
The overall objective of the proposed project is to decipher the pathways for degradation of D-mannose and D-fructose in S. solfataricus as well as D-mannose formation and utilization in S. acidocaldarius. Comparative transcriptomics, proteomics, metabolomics and crude extract measurements will be performed to assist the identification of the respective degradation pathways. The fate of carbon derived from D-mannose and D-fructose will be studied in S. solfataricus using high resolution 13C-based mass spectrometry in order to unravel the respective metabolic fluxes. The project will be a joint effort with the group of Prof. Dr. Bettina Siebers at the University of Duisburg-Essen as part of a long-standing collaboration in decoding and studying the central carbohydrate metabolism in Saccharolobus/Sulfolobus spp. and its regulation.

Your profile
· experience and background in microbiology and/or mass spectrometry
· Master’s degree (or equivalent) in the above-mentioned disciplines with an overall grade of at least ‘very good’
· English writing and communication skills
· basic experience in cultivation of microorganisms and bioinformatics analyses are desired

Our offer
· working in an interdisciplinary environment in a joint project between DSMZ Braunschweig, the Braunschweig Integrated Centre of Systems Biology (BRICS) and the University of Duisburg-Essen
· excellent facilities for biological and analytical research at our institute
· integration into a PhD graduate school at the TU Braunschweig including soft skill courses
· PhD students are encouraged to attend international conferences
· the position is offered as part time, appointment for 3 years, salary grade TV-L E13 (65%)

The DSMZ strives to increase the proportion of female scientists. Disabled applicants with identical qualification will be preferentially selected.

The DSMZ is an equal opportunity employer, supports balanced work-life career development, and holds the certificate of the audit berufundfamilie.

For further information please contact PD Dr. Meina Neumann-Schaal (meina.neumann-schaal@dsmz.de). Please send your application documents as one pdf including a CV, motivation letter, one reference letter and a synopsis of the Master’s thesis with application number 38/22 to bewerbung@dsmz.de. Applications are welcome in German or English.

The deadline for application is December 4th, 2022, or until the position is filled.
Anfangsdatum: 1. Februar 2023
Geschätzte Dauer: 3 Jahre
Bezahlung: E 13 TV-L (65 %)