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Archiv-Übersicht     Angebot Nr. 14747

Angebotsdatum: 14. Dezember 2022
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Neurologie
Titel des Themas: Glucocorticoids influence Schwann cells and macrophage responses during peripheral nerve injury

Institut: Institute of Neurobiochemistry/ Institute of Comparative Molecular Endocrinology
Adresse:
Frau Anke Rudolph-Kuhn
Albert-Einstein-Allee 11
89081 Ulm
Tel.: 0731-500 88345   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://https://www.uni-ulm.de/med/institut-fuer-neurobiochemie
E-Mail Kontakt: mail

Beschreibung: 2 PhD Students for the project “Glucocorticoids influence Schwann cells and macrophage responses during peripheral nerve injury”. This project is part of the Collaborative Research Center 1149 on trauma research.
Two positions for PhD thesis (TVL-13, 65%/ 3 years funding secured) are available at the Institute of Neurobiochemistry under the supervision of Dr. Sofia Meyer zu Reckendorf and at the Institute of Comparative Molecular Endocrinology under the supervision of PD Dr. Sabine Vettorazzi.
The preferred starting time would be as soon as possible.
Methoden: Peripheral nerve injuries (PNIs) are diagnosed in 2-3% of patients admitted to trauma centers. Although peripheral nerves have an intrinsic regeneration potential, spontaneous regeneration is limited in humans. Even after surgical intervention, the functional ability is often not restored, which leads to a severe impairment of the patients’ quality of life.
In this project, we want to explore new pharmacological ways to improve nerve regeneration. In our previously published work (Meyer zu Reckendorf et al., Nature Communications, 2020) we identified sphingosin signaling as promising candidate for the modulation of nerve regeneration ex vivo. Now, we will employ genetic approaches and glucocorticoid treatment to target sphingosin signaling in vivo using the sciatic nerve injury model in mice with a focus on Schwann cells and macrophages.
Apart from our mouse model we have the unique opportunity to investigate human nerve samples ex vivo after injury. In this case, we are interested to analyze how human nerves react to drugs modulating the sphingosin signaling. Since the initial nerve injury can date several months back until it is recognized and treated, we want to know if this latency in treatment alters the responsiveness of nerves to drug treatment.
Anfangsdatum: 14. Dezember 2022
Geschätzte Dauer: 3 years
Bezahlung: TV-L 13
Papers: If your are interested please send a cv, transcript of records and names of references until
January 31st 2023 to the following contact. Please indicate “PNI Schwann cells” or “PNI macrophages” in the subject line of your application.
Anke Rudolph-Kuhn (secretary), anke.rudolph-kuhn@uni-ulm.de
For any further inquiries concerning “PNI Schwann cells” please contact:
Dr. Sofia Meyer zu Reckendorf, sofia.meyer-zu-reckendorf@uni-ulm.de
https://www.uni-ulm.de/med/institut-fuer-neurobiochemie
For any further inquiries concerning “PNI macrophages” please contact:
PD Dr. Sabine Vettorazzi, sabine.vettorazzi@uni-ulm.de
https://www.uni-ulm.de/nawi/cme/forschung/ag-vettorazzi/
Sonstiges: www.uni-ulm.de/nawi/cme/forschung/ag-vettorazzi/

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