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Archiv-Übersicht     Angebot Nr. 14782

Angebotsdatum: 16. Januar 2023
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Materialphysik
Titel des Themas: Polymer membranes for the incorporation of nanopores

Institut: Physikalisches Institut, Experimentelle Polymerphysik
Adresse:
Dr. rer. nat. Renate Reiter
Hermann-Herder-Str. 3
79104 Freiburg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.softmatter.uni-freiburg.de
E-Mail Kontakt: mail

Beschreibung: The Polymer Physics group in Freiburg, headed by Professor Günter Reiter, has a long-standing expertise in preparation, visualisation and analysis of properties and molecular structures of ultrathin polymer films, in particular by means of atomic force microscopy at the nanometre scale. In this context, preparation of films of surface-active molecules which assemble as a monolayer at the water surface of a Langmuir trough allows to obtain almost two-dimensional monolayers in a controlled and tuneable manner.

Properties of these monolayers can be adjusted by controlling the surface density of the interfacial molecules, possibly introducing a series of phase transitions. The variability and versatility of their properties qualify these monolayers as promising candidates for model membranes, also with respect to biological applications.


Project description

In the framework of the interdisciplinary cluster Nanodiag, the Polymer Physics group will investigate and optimize such model membranes built from block copolymers or lipo-polymers for an innovative nanopore technology.

Biological nanopores can be produced from pore-forming proteins which insert into a lipid membrane and organise themselves to create a nanometre-sized channel across the membrane. These nanopores allow transport of ions and (bio)-molecules through the membrane. In biological systems, such nanopore channels regulate the transport of ions and molecules in and out of cells.

Embedded in the electrically insulating membrane, which is suspended in aqueous solution, such a nanopore can be employed as a single molecule detector which even can discriminate between different species. When voltage is applied across such a detector-membrane, a current of ions flows through the pore. The lengths and diameters of biological pores are commensurate with molecular dimensions and therefore the ionic current is blocked when a molecule is translocating through the pore. Both the duration of the blockade and the value of the residual current provide information about the interaction between the translocating species and the pore and can therefore be used to identify individual molecules.

Currently, this principle is commercial applied only for the detection and sequencing of DNA and RNA. However, in order to widen the potential application range, for example, to the identification of proteins, this technology requires further development.


Candidate profile

We are looking for a highly motivated PhD student who has a master degree in physics, chemistry, nanoscience or another related field. Experimental skills and a solid background in physics or chemistry of macromolecules are required. However, even more important is the capability to work in a multidisciplinary research team and to acquire all relevant competencies which are needed to solve underlying physical and chemical problems related to achieving suitable membrane systems for an innovative nanopore technology.

We offer an exciting field of multidisciplinary research of societal relevance, advanced and unique experimental tools as well as intensive supervision, embedded in a dynamic international team. The Experimental Polymer Physics group provides its infrastructure and know-how for the work on the PhD project.


About the position

The position is limited to 3 years. The salary will be determined in accordance with E13 TV-L. For the position advertised here, we particularly encourage applications from women.


How to apply

Please send your application including supporting documents as listed below by 15.02.2023 in written form to the following address:

Albert-Ludwigs-Universität Freiburg
Physikalisches Institut
Experimental Polymer Physics
Dr. Renate Reiter
Hermann-Herder-Str. 3
79104 Freiburg

or in electronic form to: renate.reiter@physik.uni-freiburg.de.

Supporting documents:
• Curriculum Vitae with list of publications (if applicable)
• Certified copies of your university degree(s) with grades (BA and MA certificate / Diploma certificate and transcript)
• Short summary of your master's thesis (up to 1,000 words)
• Suggestion of two referees with contact details

 

For further information, please contact Dr. Renate Reiter at +49 761 203 97782 or by e-mail: renate.reiter@physik.uni-freiburg.de.
Methoden:
Anfangsdatum: 1. März 2023
Geschätzte Dauer: 3 Jahre
Bezahlung:
Papers:
Sonstiges:

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