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Archiv-Übersicht     Angebot Nr. 14897

Angebotsdatum: 28. Juni 2023
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Anthropologie
Titel des Themas: Doctoral Project Opportunity – Novel Glutamate Sensors for Neuroscience and Biotechnology

Institut: Forschungszentrum Jülich GmbH
Frau Michalski
52428 Jülich bei Köln
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: https://www.fz-juelich.de/de/karriere/stellenangebote/2023D-060?apply
E-Mail Kontakt: mail

Beschreibung: Conducting research for a changing society: This is what drives us at Forschungs­zentrum Jülich. As a member of the Helm­holtz Asso­ciation, we aim to tackle the grand societal challenges of our time and conduct research into the possi­bilities of a digitized society, a climate-friendly energy system, and a resource-efficient economy. Work together with around 7,250 employees in one of Europe’s biggest research centres and help us to shape change!

Would you like to work on an interdisciplinary doctoral project for four years bridging different research topics and disciplines while benefiting from the expertise and supervision of experienced scientists from different institutes at Forschungszentrum Jülich? Then a project within the Jülich Program for Collaborative Doctoral Projects is just right for you. Research at Forschungszentrum Jülich addresses the very latest issues that impact our society, combining basic research with application. Being one of Europe’s biggest and most multidisciplinary research centers with a strong research infrastructure, Forschungszentrum Jülich offers unique opportunities for interdisciplinary projects. Support us researching and developing new ideas and solutions for a changing society. For more information on the Jülich Program for Collaborative Doctoral Projects, please visit: https://go.fzj.de/collaborative-doctoral-projects.

We are offering a four year

Doctoral Project Opportunity – Novel Glutamate Sensors for Neuroscience and Biotechnology
Your Job:
Glutamate is the main excitatory neurotransmitter in our brain, and impaired glutamate homeostasis causes various neurological diseases. In bacteria, glutamate is the major amino group donor and crucial for the industrial production of chemicals in white biotechnology. To understand glutamate homeostasis in these two systems, a neuroscience (IBI-1, https://www.fz-juelich.de/en/ibi/ibi-1) and a biotechnology institute (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1/forschung/systemische-mikrobiologie) have teamed up to generate novel fluorescent sensors that permit the quantification of intracellular glutamate concentrations in living cells in real time.

We are looking for a doctoral researcher who will:

Use atomistic MD simulations to optimize affinity, glutamate selectivity, and pH sensitivity of existing glutamate binding proteins in silico
Generate fluorescent glutamate sensors based on such glutamate binding proteins and characterize them with fluorescence spectroscopy and fluorescence lifetime measurements
Identify a glutamate sensor with low affinity, high selectivity for glutamate, and little pH sensitivity
Subsequently use this novel sensor to test cytoplasmic and synaptic vesicle glutamate concentrations in giant presynaptic nerve terminals in cultured neurons and cytoplasmic glutamate concentrations in selected Corynebacterium glutamicum strains to obtain information on proteins relevant for bacterial glutamate homeostasis and glutamate dynamics
Your Profile:
You are:

Holding a master’s degree in biology, chemistry, physics, or in a related field
Enjoying mathematics and computing
Finding pleasure in experimental biochemical and biological work
Interested in method development in biomedicine and biotechnology
Enjoying to combine multiple expertise and approaches
Strongly motivated for pursuing a doctoral degree within four years in an ambitious but rewarding interdisciplinary project related to neurosciences and biotechnology
Our Offer:
We offer ideal conditions for you to work on a doctoral project at the leading edge of science, including:

Excellent scientific and technical infrastructure
Continuous supervision by a team of experts
A vibrant international work environment on an attractive research campus, ideally situated between the cities of Cologne, Düsseldorf, and Aachen
Further development of your personal strengths, e.g. through an extensive range of training courses; a structured program of continuing education and networking opportunities specifically for doctoral researchers via JuDocS, the Jülich Center for Doctoral Researchers and Supervisors: https://www.fz-juelich.de/en/judocs
Extensive company health management, as well as social security and health insurance
30 days of annual leave and provision for days off between public holidays and weekends (e.g. between Christmas and New Year)
Targeted services for international employees, e.g. through our International Advisory Service
The doctoral project will be performed in the recently finished new Biocampus at Forschungszentrum Jülich, which harbors both institutes involved in this project, IBI-1 and IBG-1. This supports close interactions with members of both institutes.

In addition to exciting tasks and a collaborative working atmosphere at Jülich, we have a lot more to offer: https://go.fzj.de/benefits.

The PhD position is fixed for a term of four years. Pay will be in line with the Collective Agreement for the Public Service (TVöD-Bund).

We welcome applications from people with diverse backgrounds, e.g. in terms of age, gender, disability, sexual orientation / identity, and social, ethnic and religious origin. A diverse and inclusive working environment with equal opportunities, in which everyone can realize their potential, is important to us.

For this program it is mandatory to use and upload our CV template: https://go.fzj.de/collaborative-doctoral-projects.

We look forward to receiving your application by August 7, 2023, via our Online Recruitment System.

Questions about the Offer?
Please feel free to contact us via our contact form. Please note that for technical reasons we cannot accept applications via email.


Anfangsdatum: 8. August 2023
Geschätzte Dauer: 4 Jahre