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Archiv-Übersicht     Angebot Nr. 14938

Angebotsdatum: 11. September 2023
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Nutrient Signaling and Metabolic Control of TORC1

Institut: University of Fribourg
Prof. Claudio De Virgilio
Chemin du Musée 10
1789 Fribourg, Switzerland
Tel.: +41 26 300 8656   Fax.:
Homepage: http:// https://www.unifr.ch/bio/en/research/biochemistry/de-virgilio.html
E-Mail Kontakt: mail

Beschreibung: We look for an exceptionally motivated PhD student who holds a Master's degree in Life Sciences (from a higher education institution recognized by the University of Fribourg in Switzerland; https://www.unifr.ch/studies/en/admission/admission-doctorate-post-doctorate) with wet-lab experience and with interests in the areas outlined below. Excellent communication skills in English are an asset.

We offer:

· a stimulating, interdisciplinary scientific environment
· state-of-the-art central facilities for proteomic, imaging, and bioinformatic analyses
· a coordinated graduate program (www.unifr.ch/bio/en/studies/graduate-school-fglm/)
· a competitive Swiss salary; 4 years-funding by the Swiss National Science Foundation

The starting date for this position is earliest October 1st, 2023. Interested candidates should send a SINGLE PDF application including a CV, a brief statement of their research interests, a copy of their MSc diploma (if available), and, if possible, names of three referees by email.

Methoden: The De Virgilio Lab at the Dept. of Biology, University of Fribourg, in Switzerland, is interested in nutrient signalling pathways (including, but not limited to TORC1 signaling) and their role in the control of cell proliferation and quiescence in the model organism Saccharomyces cerevisiae (yeast). Our methodological approaches include a combination of genetic, biochemical, and molecular techniques and are aimed at understanding the basic mechanisms that control entry into, survival in, and exit from quiescence.
Anfangsdatum: 11. September 2023
Geschätzte Dauer: 3-4 years
Bezahlung: 48000.- CHF/year
Papers: Dokládal L, Stumpe M, Hu Z, Jaquenoud M, Dengjel J & De Virgilio C (2021). Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep 37, 110149.

Dokládal L, Stumpe M, Pillet B, Hu Z, Garcia Osuna GM, Kressler D, Dengjel J & De Virgilio C (2021). Global Phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control. Mol Cell 81, 1-11.

Hatakeyama R, Péli-Gulli MP, Hu Z, Jaquenoud M, Garcia Osuna GM, Sardu A, Dengjel J & De Virgilio C (2019). Spatially distinct pools of TORC1 balance protein homeostasis. Mol Cell 73, 1-14.

Hu Z, Raucci S, Jaquenoud M, Hatakeyama R, Stumpe M, Rohr R, Reggiori F, De Virgilio C & Dengjel J. (2019). Multilayered control of protein turnover by TORC1 and Atg1. Cell Rep 28, 3486-3496.