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| Angebotsdatum: |
19. September 2023
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| Art der Stelle: |
Doktorarbeit |
| Fachgebiet: |
Humanmedizin > Anatomie
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| Titel des Themas: |
Bedeutung der Koexpression und Koaktivierung von AT1-, Thromboxan A2- und EGF-Rezeptoren für Angiotensin II-vermittelte Signale in vaskulären Zellen: Analyse molekularer und funktioneller Interaktionen
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| Institut: |
Julius-Bernstein Institut für Physiologie
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| Adresse: |
| Frau Kerstin Quarch |
| Magdeburger Str. 6 |
| 06110 Halle/Saale |
| Tel.: 03455571886 Fax.:
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| Bundesland: Sachsen-Anhalt |
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| Homepage: |
https://www.verwaltung.uni-halle.de/dezern3/Ausschr/23_7_209_23_D_engl.pdf
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| E-Mail Kontakt: |
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| Beschreibung: |
The position is available as soon as possible and limited for three years.
Tasks:
• Participation in a DFG-funded project on the importance of the cooperation of vasoactive receptors in the context of vascular changes
• Carrying out experiments on vascular muscle and endothelial cells as well as in the heterologous expression system
• Implementation and evaluation of molecular biological, protein biochemical and functional cell analyses
• Data analysis, literature research and drafting of manuscripts
• There is an opportunity for your own scientific qualification as part of a doctorate
Requirements:
• Successfully completed university degree (master's, diploma) in biology, biochemistry or equivalent
• Knowledge of eukaryotic cell cultures
• Knowledge of molecular biological analyzes (e.g. qRT-PCR, ddPCR)
• Knowledge of protein biochemical analyzes (including Western Blot, ELISA)
• Basic knowledge of cell biological and functional cell analyzes (e.g. metabolism, adhesion, cell survival)
• Knowledge of spoken and written English required
• Knowledge and experience in using Office programs, literature management programs, statistical programs;
Basic knowledge of bioinformatics is desirable
• Responsible work, ability to work in a team
Applications from severely disabled persons will be given preferential consideration if they have the same suitability and qualifications. Women are strongly encouraged to apply. Applicants with a degree that was not obtained at a German university must submit a statement of comparability for foreign higher education qualifications from the Central Office for Foreign Education (https://www. kmk.org/zab/central-office-for-foreign-education).
If you have any questions, please contact Prof. Dr. Michael Gekle, email: michael.gekle@medizin.uni-halle.de.
Please send your application stating the reg. no. 7-209/23-D with the usual documents to the Martin-Luther-University Halle-Wittenberg, Medical Faculty, Julius-Bernstein-Institute for Physiology, 06097 Halle (Saale), by External Job Announcement – Registration number 7-209/23-D veröffentlicht am 18.09.2023
02/10/2023 for the attention of Mrs. Kerstin Quarch (kerstin.quarch@medizin.uni-halle.de) or to Prof. Dr. Michael Gekle (michael.gekle@medizin.uni-halle.de).
The tender is subject to any budgetary restrictions.
Application costs will not be reimbursed by Martin Luther University. Application documents will only be returned if a sufficiently stamped return envelope is enclosed. An electronic application is preferred.
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| Methoden: |
• Carrying out experiments on vascular muscle and endothelial cells as well as in the heterologous expression
system
• Implementation and evaluation of molecular biological, protein biochemical and functional cell analyses
• Data analysis, literature research and drafting of manuscripts
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| Anfangsdatum: |
1. November 2023 |
| Geschätzte Dauer: |
three years
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| Bezahlung: |
65% TVL-13 E (~ 1800 € netto)
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| Papers: |
The F2-isoprostane 8-iso-PGF2α attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A2 receptors. - Braun H, Hauke M, Eckenstaler R, Petermann M, Ripperger A, Kühn N, Schwedhelm E, Ludwig-Kraus B, Kraus FB, Dubourg V, Zernecke A, Schreier B, Gekle M, Benndorf RA. Free Radic Biol Med. 2022 May 20;185:36-45. doi: 0.1016/j.freeradbiomed.2022.04.010. Epub 2022 Apr 22.
The Functional Interaction of EGFR with AT1R or TP in Primary Vascular Smooth Muscle Cells Triggers a Synergistic Regulation of Gene Expression.
Dubourg V, Schreier B, Schwerdt G, Rabe S, Benndorf RA, Gekle M.
Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation.
Schreier B, Dubourg V, Hübschmann S, Rabe S, Mildenberger S, Gekle M. Cell Mol Life Sci. 2021 Dec 18;79(1):57. doi: 10.1007/s00018-021-04065-5.
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