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Archiv-Übersicht     Angebot Nr. 15099

Angebotsdatum: 23. Mai 2024
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Tiermedizin > Ambulatorische & Geburtshilfliche Tiermedizin
Titel des Themas: The role of regulatory T-cells and type-17 T-cells in testicular tumors and testicular inflammation

Institut: Institute for Veterinary Anatomy, Histology and Embryology
Frau Faiqa Hossain
Leihgesterner Weg 52
35392 Giessen
Tel.:    Fax.:
E-Mail Kontakt: mail

Beschreibung: In this doctoral project, state-of-the-art methods (including RNA sequencing, CODEX, flow cytometry) will be used in close collaboration between the Departments of Veterinary Medicine and Medicine at Justus Liebig University and the Institute of Systems Immunology at Philipps University Marburg to analyze the involvement of the immune system in the development of testicular tumors and spermatogenesis disorders. The analysis of the immune cells involved, with a particular focus on T cells, is carried out both ex vivo on tissue samples obtained both in cases of suspected tumors and routinely in cases of male infertility, and supplemented by in vitro models. You will classify the tissue samples morphologically, immunohistochemically and molecular biologically according to standard examination methods and describe the immune cell populations present in normal and impaired spermatogenesis as well as in precursors to malignant germ cell tumors and manifest testicular cancer. In cell culture experiments with downstream analysis of gene expression and cytokine release, you will identify functional relationships and decipher communication pathways between tumor cells, somatic cells, and immune cells in the human testis.
The provision of scientific services (including the processing of a research project financed by third-party funds for a limited period of time) also serves as a scientific qualification.
Methoden: Your qualifications and skills
-Completed scientific university degree in biology, biochemistry, immunology, medicine or comparable disciplines
- High interest in reproductive immunology and tumor immunology, as well as fundamental enjoyment of analytical-conceptual scientific and laboratory work
- Ability to work independently, motivation, initiative and willingness to learn and apply immunological and molecular biological techniques
- Previous knowledge in the field of reproductive immunology, molecular biology and cell culture is an advantage.
- Very good written and spoken English skills are required as well as basic scientific working techniques
- Personally, you are characterized by an above-average level of motivation, commitment and the ability to work in a team.
Anfangsdatum: 1. August 2024
Geschätzte Dauer: 4 years
Bezahlung: 65% of E 13 Hessen Tarif part-time position
Sonstiges: Our offer to you
-In a dynamic international working environment, we offer you state-of-the-art technologies to carry out varied and responsible research tasks
- You can present your research results at national and international scientific conferences
- You will be part of a structured qualification program for doctoral students at the International Giessen Graduate Centre for the Life Sciences (GGL, https://www.uni- giessen.de/de/fbz/zentren/ggl)
- A varied job with flexible working hours
- Free use of local public transport (LandesTicket Hessen)
- More than 100 seminars, workshops and e-learning opportunities per year for personal development as well as a wide range of health and sports activities
- Remuneration according to TV-H, company pension scheme, child allowance and special payments
- Good compatibility of family and career (certificate "audit family-friendly university")

If you have any further questions, please contact Prof. Dr. Daniela Fietz by e-mail (Daniela.Fietz@vetmed.uni- giessen.de).

Apply via this link https://www.uni-giessen.de/karriere/stellenangebote/ausschreibungen/wissenschaftliche-mitarbeiter/366-10-e by 11.06.2024, quoting the reference number 366/10. We look forward to receiving your application.