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| Angebotsdatum: |
17. November 2024
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| Art der Stelle: |
Doktorarbeit |
| Fachgebiet: |
Humanmedizin > Chirurgie
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| Titel des Themas: |
Molecular mechanisms of CO2-sensing
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| Institut: |
Justus Liebig University Giessen
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| Adresse: |
| PD Moritz Dr. Dr. Strowitzki (MD, PhD) |
| Rudolf-Buchheim-Str. 7 |
| 35358 Gießen |
| Tel.: Fax.:
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| Bundesland: Hessen |
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| Homepage: |
www.strowitzkilab.com
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| E-Mail Kontakt: |
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| Beschreibung: |
The position is part of the project "Molecular mechanisms of CO2-sensing and their significance during healing of intestinal anastomoses", and is externally funded by the German Research Foundation (DFG) within the Emmy Noether Programme. The position is to be filled on a fixed-term basis in accordance with § 2 WissZeitVG and § 72 HessHG with the opportunity for own academic qualification at the Department of Surgery at the Faculty of Medicine. The salary is in accordance with the collective labor agreement of the State of Hessen (E 13 TV-H).
As long as the maximum permissible duration of a fixed-term contract is not exceeded, you will be employed for an initial period of 3 years. An extension for up to another 2 years is possible under the above-mentioned condition.
The research group is located in the Science Tower of University Hospital Giessen adjacent to the German Center for Lung Research (DZL), offering a vibrant and stimulating environment for young researchers. During the project, we will investigate novel molecular CO2-sensing mechanism and their effect on macrophage differentiation and activation. In addition, the effect of CO2 and CO2-adaptive signaling pathways on healing and regeneration of the gut will be determined.
The PhD position will be embedded in the local graduate program International Giessen Graduate Centre for the Life Sciences (GGL) with outstanding training opportunities in interconnected research fields and a well-established mentoring program. Students will benefit from state-of-the-art technologies in molecular biology and basic science in an internationally completive scientific training program.
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| Methoden: |
Your tasks at a glance
• Cell culture experiments (hypoxia chamber) and assays (e.g., western blotting, RT-PCR, real-time flow cytometry)
• Performing immunohistochemistry and spatial omics experiments (10x genomics®, Nano-string®)
• Training in micro-surgery and animal handling
• Tissue handling of patient samples
• Analysis and data presentation during group meetings, national and international conferences, and publications in scientific journals
• Supervision of MD- and Master-students
• Development of an own scientific profile during the PhD thesis
The provision of academic services (including the processing of a research project financed by third party funds on a temporary basis) also serves the purpose of academic qualification.
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| Anfangsdatum: |
1. Dezember 2024 |
| Geschätzte Dauer: |
5 years
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| Bezahlung: |
E 13 TV-H
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| Papers: |
Strowitzki MJ, Nelson R, Garcia MP, Tuffs C, Bleul MB, Fitzsimons S, Navas J, Uzieliene I, Ritter AS, Phelan D, Kierans SJ, Blanco A, Bernotiene E, Belton O, Schneider M, Cummins EP, Taylor CT. Carbon dioxide sensing by immune cells occurs through carbonic anhydrase 2–dependent changes in intracellular pH. J Immunol. 10, 2363-2375 (2022)
Cummins EP, Strowitzki MJ, Taylor CT. Mechanisms and consequences of oxygen-and carbon dioxide-sensing in mammals. Physiol. Rev. 100, 463-488 (2020)
Phelan DE, Mota C, Strowitzki MJ, Shigemura M, Sznajder JI, Crowe L, Masterson JC, Hayes SE, Reddan B, Yin X, Brennan L, Crean D, Cummins EP. Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes. Immunol. Cell Biol. 101, 556-577 (2023)
Strowitzki MJ, Kimmer G, Wehrmann J, Ritter AS, Radhakrishnan P, Opitz VM, Tuffs C, Biller M, Kugler J, Keppler U, Harnoss JM, Klose J, Schmidt T, Blanco A, Taylor CT, Schneider M. Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses. JCI Insight. 6, e139191 (2021)
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| Sonstiges: |
send email or apply under:
https://www.uni-giessen.de/de/ueber-uns/karriere/application
pls always indicate the reference number 695/11
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