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The Mayer Lab, Mainz is excited to announce openings for up to 3 fully funded PhD positions. We invite highly motivated candidates to join a dynamic, interdisciplinary research environment, with projects at the forefront of infectious disease and immunology. Successful applicants will engage in innovative research in collaboration with renowned institutions, including the Center for Research Center for Immunotherapy, the Center for Thrombosis and Haemostasis, and the Helmholtz-Institute for Translational Oncology
We offer:
• cutting-edge research and training opportunities with access to state-of-the-art facilities, single-cell phenotyping and interactome studies, specific mouse models and translational approaches
• an excellent scientific network
• a prestigious graduate school program with a project-adapted curriculum (training courses, lectures etc on scientific, technical and complementary skill topics) and a strong and active PhD community
• the opportunity for travel to present your work
• a stimulating international and multi-disciplinary research environment at the University Center Mainz Campus with close interactions between students, clinicians and researchers
The following PhD projects are available and will start between March and June 2025:
• Dendritic Cell reprogramming by chronic helminth infection – coevolution vs immune cell exhaustion
• Tissue-specific features of local dendritic cells - causes of niche specific differentiation and therapeutic potential
• Dendritic Cell reprogramming within the tumor microenvironment – early biomarkers and the establishment of a field effect
Our lab focuses on understanding Dendritic Cell function in health and disease. (Mayer, Nature Communications 2017; Bosteels, Immunity 2020; Hilligan, Nature Communications, 2020, Mayer, Nature Immunology, 2021), we hypothesize that DC perform tissue and niche specific roles in tissue homeostasis and disease. Our preliminary data show that local as well as systemic changes influence the differentiation and function of DC, creating an important feed-forward loop in beneficial and detrimental immunity. To address these responses we utilize advanced single-cell technologies (high-dimensional flow cytometry, multiplex imaging, single-cell sequencing) and highly specific mouse models to define short-term and long-term modifications of DC in homeostatic and disease associated niches.
We are looking for:
• creative and highly motivated candidates (w/d/m) of all nationalities and backgrounds who are truly committed to research
• applicants with a strong background in biological sciences, a good understanding in immunology, initial experience in working with mouse models and complex single-cell phenotyping data are invited to apply
• candidates must have an excellent M.Sc. or equivalent degree (it is not necessary to hold the final degree at the time of application however the degree should be fully completed before project start)
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